Mutational Analysis of the Absolutely Conserved B8Gly: Consequence on Foldability and Activity of Insulin
نویسندگان
چکیده
منابع مشابه
Mutational analysis of the absolutely conserved B8Gly: consequence on foldability and activity of insulin.
B8Gly is absolutely conserved in insulins during evolution. Moreover, its corresponding position is always occupied by a Gly residue in other members of insulin superfamily. Previous work showed that Ala replacement of B8Gly significantly decreased both the activity and the foldability of insulin. However, the effects of substitution are complicated, and different replacements sometimes cause s...
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ژورنال
عنوان ژورنال: Acta Biochimica et Biophysica Sinica
سال: 2005
ISSN: 1672-9145,1745-7270
DOI: 10.1111/j.1745-7270.2005.00093.x